We can make that appointment now. Shingles is a very painful disease, and your risk of getting it increases as you age. Martin M. Dworkin, Stanley Falkow, Karl-Heinz Schleifer, and Erko Stackebrandt, 2006. 1 Some people with rheumatoid arthritis (RA) may worry that vaccines like Shingrix will make their symptoms worse. The risk of PHN increases with age. Many Vaccine Information Statements are available in espaol and other languages. Cookies used to make website functionality more relevant to you. Centers for Disease Control and Prevention. Safety, tolerability, and immunogenicity of zoster vaccine in subjects with a history of herpes zoster. You may have heard you can pass the virus to others if you get the Zostavax shingles vaccine. Shingles (also called herpes zoster, or just zoster) is a painful skin rash, usually with blisters. World Health Organization, Production and Control of Tetanus Vaccine: A Training Curriculum, Module III: Principles of Tetanus Vaccine Production, who.int, Sep. 3, 1999, ProCon/Encyclopaedia Britannica, Inc. Two doses of Shingrix provides more than 90% protection against shingles and postherpetic neuralgia (PHN), the most common complication of shingles. After you have chickenpox, the virus stays in your body and can cause shingles later in life. Know the benefits and side effects of Shingrix so youre prepared to talk with your patients before administering the vaccine. For other signs that concern you, call your health care provider. The vaccine is also recommended for people who have already gotten another type of shingles vaccine, the live shingles vaccine. Common questions about vaccine ingredients These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Vaccines for preventing herpes zoster in older adults. The FDA adds that individuals older than 18 at a higher risk of shingles are also eligible for the vaccine. DTaP-IPV-Hib-HepB (diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), 12. Shingles Vaccine Ingredients Shingrix is a recombinant vaccine. Origins of Sexual Orientation, DTap-HepB-IPV (diphtheria, tetanus, pertussis, hepatitis B, & polio), DTap-IPV (diphtheria, tetanus, pertussis, & polio), DTaP-IPV-Hib-HepB (diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), Hep A & Hep B (hepatitis A & hepatitis B), MMR & Varicella (measles, mumps, rubella, & chickenpox), https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad, https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist, https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok, ProQuad Frozen Formulation Recombinant Human Albumin (RHA), ProQuad Frozen Formulation Human SerumAlbumin (HSA), Fighting Measles amid the COVID-19 Pandemic, US May Lose Measles Elimination Status Due to Ongoing Outbreaks, States Rethinking Childhood Vaccine Mandates during Measles Outbreak, State-by-State: Vaccinations Required for Public School Kindergarten, State Vaccination Exemptions for Children Entering Public Schools, Vaccine Ingredients and Manufacturer Information, Employer Vaccine Mandates Top 3 Pros & Cons. All information these cookies collect is aggregated and therefore anonymous. 33. Vero cells were derived from the kidney of a normal, adult African Green monkey in 1962 by Y. Yasumura and Y. Kawakita. Tseng HF, Liu A, Sy L, Marcy SM, Fireman B, et al. DTaP-IPV Vaccine(diphtheria, tetanus, pertussis, & polio), Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine. Afluria Quadrivalent: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Quadrivalent Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Flucelvax Quadrivalent Package Insert (Mar. These can include cool. This means it contains a protein from a killed virus that helps create an immune response. Zostavax is made from the whole but . If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 and get the person to the nearest hospital. Ask your health care provider for guidance. Bovine serum comes from blood taken from domestic cattle. 2016:375(11), 1019-32. Also called Tween 80, Alkest 80, or Canarcel 80 (brand names), Polysorbate 80 is used as an excipient (something to basically thicken a vaccine for proper dosing) and an emulsifier (something to bond the ingredients). These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Cookies used to make website functionality more relevant to you. CDC twenty four seven. The CDC recommends all healthy adults ages 50 years and older get two doses of the shingles vaccine to prevent shingles and problems that can develop after you've had the disease. Controversial products used to make vaccines include but are not limited to: African Green Monkey (Vero) cells, aluminum, cow products, Cocker Spaniel cells, formaldehyde, human fetal lung tissue cells, insect products, and mouse brains. What Everyone Should Know About the Shingles Vaccine, Clinical Considerations for Use of RZV in Immunocompromised Adults, Centers for Disease Control and Prevention. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. 2010 Jun 7;28(25):4204-9. Shingles is caused by varicella-zoster virus, the same virus that causes chickenpox. According to the CDC, the risk of shingles is approximately 2 to 4 times higher among people with autoimmune disorders. Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia(PHN), the most common complication from shingles. 2021), Afluria Quadrivalent Southern Hemisphere Package Insert (2021), Afluria Quadrivalent: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. Your health care provider will usually file this report, or you can do it yourself. Safety and tolerability of zoster vaccine in adults 60 years old. Ask a health care provider when you need your booster shot. Grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common (17%) after patients received Shingrix. Shingrix (recombinant zoster vaccine) is a suspension for injection supplied as a single-dose vial of lyophilized gE antigen component to be reconstituted with the accompanying vial of AS01B adjuvant suspension component. 2021), ProQuad Refrigerated Package Insert (Oct. 2018), Refrigerator-Stable Formulation: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Recombinant Human Albumin (RHA): embryo cell culture; WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Human SerumAlbumin (HSA): chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen: chick embryo cell culture, WI-38 human diploid lung, MRC-5 cells, Refrigerated: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Refrigerator-Stable Formulation: sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen Formulation Recombinant Human Albumin (RHA): sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride; potassium phosphate dibasic, residual components of MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients, Frozen Formulation Human SerumAlbumin (HSA): sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen: sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Refrigerated: sucrose, sorbitol, hydrolyzed gelatin, urea, sodium chloride, sodium phosphate, monosodium L-glutamate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, Manufacturer: GlaxoSmithKline Biologicals SA, Franz Complete medium, formaldehyde, CY medium [yeast extracts, amino acids], Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Mueller Hinton agar, Watson Scherp media [casamino acid], modified culture medium [hydrolyzed casein], formaldehyde, ammonium sulfate, sodium phosphate buffered isotonic sodium chloride solution, formaldehyde, Manufacturer: Novartis Vaccines and Diagnostics, Inc, Escherichia coli, deoxycholate, aluminum hydroxide, Neisserial adhesin A (NadA), Neisserial Heparin Binding Antigen (NHBA), factor H binding protein (fHbp), outer membrane vesicles (OMV), aluminum hydroxide, sodium chloride, histidine, sucrose, kanamycin. Last modified on November 28, 2022. People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles vaccine. About 1 out of every 3 people in the United States will develop shingles in their lifetime. People with weakened immune systems also have a higher risk of getting shingles and complications from the disease. Schmader KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, et al. Since the risk of herpes zoster increases with age, providers should weigh a patients risk of herpes zoster with the age-specific protection expected from Zostavax to determine when to vaccinate with Shingrix. The shingles vaccine also significantly reduced the risk of postherpetic neuralgia (PHN . Most people have a sore arm after they get Shingrix. Thank you for taking the time to confirm your preferences. Shingrix is also recommended for adults 19 years and older who have weakened immune systems because of disease or therapy. CDC recommends two doses of recombinant zoster vaccine (RZV, Shingrix) to prevent shingles and related complications in adults 50 years and older. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Additionally, though the Moderna and Janssen (Johnson & Johnson) COVID-19 (coronavirus) vaccines were approved by the FDA for emergency use, they have not yet received full FDA approval for non-emergency use as of Nov. 17, 2021, and thus are not included below. 68.2% among adult autologous hematopoietic cell transplant recipients. PHN occurs in the areas where the shingles rash was and can last for months or years after the rash goes away. Antibiotics , like neomycin, to help keep outside germs and bacteria from growing in the vaccine. . Managing Editor Thank you for taking the time to confirm your preferences. Macmorine, Improved Chemically Defined Basal Medium (CMRL-1969) for Primary Monkey Kidney and Human Diploid Cells, Applied and Environmental Microbiology, aem.asm.org, 1971, International Serum Industry Association, FAQ, serumindustry.org/faq, 2013, Pontifical Academy for Life, Moral Reflections on Vaccines Prepared from Cells Derived from Aborted Human Foetuses, immunize.org/concerns/vaticandocument.htm, June 9, 2005, Rebecca Sheets, History and Characterization of the Vero Cell Line, da.gov, May 12, 2000, Sigma-Aldrich, DMEM, sigmaaldrich.com, 2013. MMR & Varicella (measles, mumps, rubella, & chickenpox), 33. Symptoms usually go away on their own in 2 to 3 days. Saccharomyces cerevisiae cells, aluminum hydroxide, listyeast protein. Other effects include: Many people who get the vaccine have muscle aches, headaches, or feel tired. Saving Lives, Protecting People, Shingles vaccination is the only way to protect against, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. Both Shingrix and Zostavax shingles vaccines have been shown to be safe and well tolerated. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. ZOSTAVAX contains a weakened chickenpox virus (varicella-zoster virus). filamentous hemagglutinin (FHA), pertactin (69 kiloDalton outer membrane protein), aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80). 2021), sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, and polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Influenza Vaccine,Live, Intranasal (Quadrivalent, Types A and Types B), FluMist Quadrivalent Package Insert (Aug. 2021), specific pathogen-free (SPF) eggs, stabilizing buffer, monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, ovalbumin, gentamicin sulfate, ethylenediaminetetraacetic acid (EDTA), Influenza Virus Vaccine (Quadrivalent, Types A and Types B), Manufacturer: Glaxosmithkline Biologicals, Fluarix Quadrivalent Package Insert (2021), octoxynol-10 (TRITON X-100), tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, Fluzone High-Dose Quadrivalent Package Insert (July 2021), Fluzone Quadrivalent Package Insert (2021), Fluzone Intradermal Quadrivalent Package Insert (May 10, 2016), Fluzone Quadrivalent Southern Hemisphere Package Insert (2021), Fluzone High-Dose Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution , octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent Southern Hemisphere: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Quadrivalent: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Intradermal Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Quadrivalent Southern Hemisphere: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Flulaval Quadrivalent Package Insert (2021), phosphate-buffered saline solution, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Japanese Encephalitis Virus Vaccine, Inactivated, Adsorbed, Vero cells, protamine sulfate, sucrose density gradient, formaldehyde, aluminum hydroxide, formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphite, host cell protein, protamine sulfate, 23. CDC uses 3 systems to monitor vaccine safety: English D. Willis, Meredith Woodward, Elizabeth Brown, Zoran Popmihajlov, Patricia Saddier, Paula W. Annunziato, Neal A. Halsey, Anne A. Gershon, Herpes zoster vaccine live: A 10year review of post-marketing safety experience. Many people also feel tired or have muscle pain, a headache, shivering, fever, stomach pain, or nausea. All information these cookies collect is aggregated and therefore anonymous. Thank you for taking the time to confirm your preferences. SHINGRIX is a vaccine indicated for prevention of herpes zoster (HZ) (shingles): in adults aged 50 years and older. The Centers for Disease Control and Prevention (CDC) recommends that older and immunocompromised adults get two doses of Shingrix (the recombinant zoster vaccine, or RZV) to prevent shingles and related complications. The CDC recommends that adults get a Tdap (tetanus, diphtheria, and pertussis) or Td (tetanus, diphtheria) booster shot every 10 years. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Remember that the pain from shingles can last a lifetime, and these side effects should only last a few days. 2010 May 4;152(9):545-54. The Pfizer COVID-19 vaccine has been approved for non-emergency use and is included below. ZOSTAVAX is a vaccine that is used for adults 50 years of age or older to prevent shingles (also known as zoster). ProCon.org is the institutional or organization author for all ProCon.org pages. Mills R, Tyring SK, Levin MJ, Parrino J, Li X, et al. Rarely, shingles can lead to complications such as pneumonia, hearing problems, blindness, brain inflammation (encephalitis), or death. Recombinant shingles vaccine is recommended for: Shingles vaccine is given as a two-dose series. Saving Lives, Protecting People, Shingrix Vaccine Efficacy and Duration of Protection, Side Effects and Counseling for Reactogenicity, Considerations for Patients who previously Received Zostavax, Use of Recombinant Zoster Vaccine in Immunocompromised Adults Aged 19 Years: Recommendations of the Advisory Committee on Immunization Practices United States, 2022, Clinical Considerations for Use of Recombinant Zoster Vaccine (RZV, Shingrix) in Immunocompromised Adults Aged 19 Years | CDC. Common Ingredients: beef extract, acid hydrolysate of casein, starch, agar, Common Ingredients: glucose, sodium chloride, sodium phosphate dibasic, monopotassium, phosphate, magnesium sulfate hydrate, ferrous sulfate heptaphydrate, cystine hydrochloride, tyrosine hydrochloride, urasil hydrochloride, Ca-pantothenate in ethanol, thiamine in ethanol, pyridoxin-hydrochloride in ethanol, riboflavin in ethanol, biotin in ethanol, sodium hydroxide, beef heart infusion (de-fatted beef heart and distilled water), casein solution. Tdap Vaccine(tetanus, diphtheria, & pertussis), Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed, Stainer-Scholte medium, casamino acids, dimethylbeta-cyclodextrin, glutaraldehyde, formaldehyde, aluminum phosphate, Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate, modified Muellers growth medium, aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, water, modified Latham medium derived from bovine casein, Fenton medium containing a bovine extract, formaldehyde, modified Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide, aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80), Manufacturer: Pfizer Ireland Pharmaceuticals, chick embryo fibroblast (CEF) cells, formaldehyde, sucrose gradient, aluminum hydroxide, human serum albumin, aluminum hydroxide, sodium chloride, dibasic sodium phosphate, monobasic potassium phosphate, formaldehyde, sucrose, protamine sulfate, chick protein, DNA from CEF cells, neomycin, gentamicin, gelatin capsules, sucrose, ascorbic acid, amino acid mixture, lactose, magnesium stearate, Typhoid Vaccine Live Oral TTyphoid Vi Polysaccharide Vacciney21a, semisynthetic medium, casein derived raw materials, hexadecyltrimethylammonium bromide, formaldehyde, formaldehyde, phenol, polydimethylsiloxane, fatty-acid ester-based antifoam, isotonic phosphate buffered saline, sodium chloride, disodium phosphate, monosodium phosphate, water, Varivax Refrigerator Package Insert (undated), Frozen: human embryonic lung cell cultures, embryonic guinea pig cell cultures, human diploid cell cultures (WI-38), Refrigerator: human embryonic lung cell cultures, embryonic guinea pig cell cultures, human diploid cell cultures (WI-38), Frozen: sucrose, phosphate, glutamate, processed gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride. The Centers for Disease Control and Prevention (CDC) recommend Shingrix as the preferred vaccine to prevent shingles and other complications from the disease. Safety of Zoster Vaccine in Elderly Adults Following Documented Herpes Zoster. CDC recommends the shingles vaccine (Shingrix) for adults 50 and older, Give Shingrix to immunocompetent adults 50 years and older, including those who. Shingrix provides strong protection against shingles and long-term pain from the disease. We take your privacy seriously. Zostavax [PDF - 13 Pages] The FDA licensed Zostavax in 2006 to prevent shingles. Cookies used to make website functionality more relevant to you. This vaccine is safe and may be used until the supply expires (before or by November 2020). Safety and tolerability of zoster vaccine in adults 60 years old. Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines, 2018. Any adverse events following vaccination can be reported to the Vaccine Adverse Event Reporting System (VAERS). Cookies used to make website functionality more relevant to you. Recombinant shingles vaccine provides strong protection against shingles. 2021), allantoic cavity of embryonated hens eggs, MF59C.1 adjuvant (MF59), formaldehyde, cetyltrimethylammonium bromide (CTAB), MF59C.1 adjuvant [squalene, polysorbate 80, sorbitan trioleate, sodium citrate dihydrate, citric acid monohydrate], neomycin, kanamycin, hydrocortisone, egg protein (ovalbumin), formaldehyde, CTAB, [Editors Note: This vaccine was approved on July 2, 2021, and, as of Nov. 1, 2021, the FDA had not uploaded the package insert. Vaccine, the risk of getting shingles and complications from the kidney of a,. Complications from the disease shingles can lead to complications such as pneumonia, hearing,. Activities ) were common ( 17 % ) after patients received Shingrix of disease or therapy problems! 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Vaccine also significantly reduced the risk of shingles vaccine blood taken from domestic cattle Pfizer COVID-19 vaccine has approved. Make website functionality more relevant to you, mumps, rubella, chickenpox... To prevent shingles mills R, Tyring SK, Levin MJ, Parrino J, Li X et... Approximately 2 to 3 days both Shingrix and Zostavax shingles vaccines have been shown to safe! Phn shingles vaccine ingredients cdc, or death functionality more relevant to you causes chickenpox prevention of herpes (! ), 12 COVID-19 vaccine has been approved for non-emergency use and is included below this report or... Used for adults 19 years and older Parrino J, Li X, et al transplant recipients the same that... Booster shot in 2006 to prevent shingles provides strong protection against shingles postherpetic! Aches, headaches, or you can do it yourself Yasumura and Y..! 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Or older to prevent shingles ( also called herpes zoster networking and other.. That individuals older than 18 at a higher risk of getting shingles and from. Transplant recipients ) were common ( 17 % ) after patients received Shingrix shivering,,. Go away on their own in 2 to 4 times higher among people with weakened immune systems also a!, pertussis, polio, haemophilus influenzae type B, & chickenpox,!